The impacts of complex and changeable external environment on traditional management are analyzed．The collaboration-in-latitude of main reform management method based on process is proposed to avoid the confliction of multiple actions and to provide synergistic effect of multiple methods．The integration-in-longitude from strategy to implementation based on the logical relationship of process value is studied to provide main line of alingnment and synthesis for the implementation of total enterprise strategy，the enhance of total performance and operational management． The collaboration and synthesis management framework and system based on process is built up to provide a scientific and effective method for dealing with the challenge and complexity of rapid change．